The discovery of molecule candidates for further drug development is typically accomplished using cell culture-based models. However, there are instances when molecules that exhibit activity at the cellular level show low or no activity at the organ or organism level. As we ascend through biological levels, the biological complexity increases, presenting molecules with greater challenges and interactions.

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Isolated organ systems serve as ex vivo models that can provide a more accurate representation of diseases. However, the application of organ systems for screening and primary identification of molecules is limited due to low throughput and is primarily used for known hits.

 

Currently, isolated heart and brain models are employed at Mitopharma for modeling mitochondrial dysfunction and damage. ​